Yes, Cool Calc can be used to perform a load calculation on a home that contains radiant flooring.
In the floor section the user must select floor type = "radiant" as shown in the screenshot below.
Cool Calc will automatically make the necessary adjustments to the heating temperature difference across the floor since the HTD values for a radiant floor are considerably higher than a standard HTD.
Cool Calc will also omit the radiant floor load from the duct load calculations since duct load is calculated as a percentage of the load subtotal.
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